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Therefore, Tregs actively regulate AC activity by degrading cAMPwith PDEs and as previously discussed, cAMP through CREB inhibition of transcription canrestrain Treg proliferation as long as cAMP is present. Figure 3.5 shows their results for the effect of bolus volumeon oral transit time and Figure 3.6 shows their results for the effect of bolus volume on dura-tion of cricopharyngeal opening

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